PUBLICACIONES

Publicaciones últimos 5 años (2018-2022):

> Sampedro-Piquero P, Moreno-Fernández RD, Begega A, López M, Santín LJ. Long-term consequences of alcohol use in early adolescent mice: Focus on neuroadaptations in GR, CRF and BDNF. Addict Biol. 2022 Mar;27(2):e13158. doi: 10.1111/adb.13158.

> Flores-Burgess A, Millón C, Gago B, García-Durán L, Cantero-García N, Puigcerver A, Narváez JA, Fuxe K, Santín L, Díaz-Cabiale Z. Galanin (1-15) Enhances the Behavioral Effects of Fluoxetine in the Olfactory Bulbectomy Rat, Suggesting a New Augmentation Strategy in Depression. Int J Neuropsychopharmacol. 2022 Apr 19;25(4):307-318. doi: 10.1093/ijnp/pyab089.

> Cantero-García N, Flores-Burgess A, Ladrón de Guevara-Miranda D, Serrano A, García-Durán L, Puigcerver A, Fuxe K, Narváez JÁ, Santín LJ, Díaz-Cabiale Z, Millón C. The Combination of Galanin (1-15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression. Biomedicines. 2022 Feb 9;10(2):412. doi: 10.3390/biomedicines10020412.

> Mañas-Padilla, M.C., Ávila-Gámiz, F., Gil-Rodríguez, S., Sánchez-Salido, L., Santín, L.J., Castilla-Ortega, E. (2022). Working and Reference Memory Impairments Induced by Passive Chronic Cocaine Administration in Mice. In: Aguilar, M.A. (eds) Methods for Preclinical Research in Addiction. Neuromethods, vol 174. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1748-9_11.

> León-Rodríguez, A., Fernández-Arjona, M., Grondona, J.M. Pedraza C., López-Avalos, MD. (2022). Anxiety-like behavior and microglial activation in the amygdala after acute neuroinflammation induced by microbial neuraminidase. Scientific Report 12, 11581. https://doi.org/10.1038/s41598-022-15617-5.

> Bartolomé, G., Vila, S., Torrelles-Nadal, C., Blanco E (2022) Right Cortical Activation During Generation of Creative Insights: An Electroencephalographic Study of Coaching. Frontiers in Education. 7:753710. doi: https://doi.org/10.3389/feduc.2022.753710

> Luque-Rojas MJ, Blanco Calvo E and Martín-Aragoneses MT (2022) Editorial: Neuroscience, learning, and educational psychology. Frontiers in Psychology. 13:928054. doi: https://doi.org/10.3389/fpsyg.2022.928054

> Martín-Montañez E, Valverde N, Ladrón de Guevara-Miranda D, Lara E, Romero-Zerbo YS, Millon C, Boraldi F, Ávila-Gámiz F, Pérez-Cano AM, Garrido-Gil P, Labandeira-Garcia JL, Santin LJ, Pavia J, Garcia-Fernandez M. Insulin-like growth factor II prevents oxidative and neuronal damage in cellular and mice models of Parkinson's disease. Redox Biol. 2021 Oct;46:102095. doi: 10.1016/j.redox.2021.102095.

> García-Duran L, Flores-Burgess A, Cantero-García N, Puigcerver A, Narváez JA, Fuxe K, Santín LJ, Millón C, Diaz-Cabiale Z. Galanin (1-15) potentiates the antidepressant-like effects induced by escitalopram in a rat model of depression. International Journal of Molecular Sciences. 2021. 22(19), 10848. doi.10.3390/ijms221910848.

> Flores-López M, García-Marchena N, Pavon JF, Lara E, Porras-Perales O, Araos P, Requena-Ocaña N, Torres-Galván S, Mañas-Padilla MC, Rubio G, Suárez J, Santín LJ, Rodriguez de Fonseca F, Castilla-Ortega E, García-Fernandez M, Serrano A. Plasma Concentrations of Lysophosphatidic Acid and Autotaxin in Abstinent Patients with Alcohol Use Disorder and Comorbid Liver Disease. Biomedicines. 2021. 9(9):1207. doi: 10.3390/biomedicines9091207.

> Mañas-Padilla MC, Ávila-Gámiz F, Gil-Rodríguez S, Ladrón de Guevara-Miranda D, Rodríguez de Fonseca F, Santín LJ, Castilla-Ortega E. Persistent changes in exploration and hyperactivity coexist with cognitive impairment in mice withdrawn from chronic cocaine. Physiology & Behavior, 2021. 240: 113542. doi: 10.1016/j.physbeh.2021.113542.

> Nieto-Quero A, Chaves-Peña P, Santín LJ, Pérez-Martín M, Pedraza C. Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models. Neurobiology of Stress, 2021. 15: 100356. doi: 10.1016/j.ynstr.2021.100356.

> Rosell-Valle C, Martinez-Losa MM, Matas-Rico E, Castilla-Ortega E, Zambrana-Infantes E, Gómez-Conde AI, Sánchez-Salido L, Ladrón de Guevara-Miranda D, Pedraza C, Serrano-Castro PJ, Chun J, Rodríguez De Fonseca F, Alvarez-Dolado M, Santín LJ, Estivill-Torrús, G. GABAergic deficits in absence of LPA1 receptor, associated anxiety-like and coping behaviors, and amelioration by interneuron precursor transplants into the dorsal hippocampus. Brain Structure and Function, 2021. 226(5):1479-1495. doi: 10.1007/s00429-021-02261-4.

> Rosell-Valle C, Pedraza C, Manuel I, Moreno-Rodríguez M, Rodríguez-Puertas R, Castilla-Ortega E, Caramés JM, Gómez-Conde, AI, Zambrana-Infante EN, Ortega-Pinazo J, Serrano-Castro P, Chun J, Rodríguez de Fonseca F, Santín LJ, Estivill-Torrús G. Chronic central modulation of LPA/LPA receptors-signaling pathway in the mouse brain regulates cognition, emotion, and hippocampal neurogénesis. Progress in Neuropsychopharmacology & Biological Psychiatry, 2021. 108:110156. Doi: 10.1016/j.pnpbp.2020.110156.

> Cárdenas J, Blanca MJ, Carvajal F, Rubio S, Pedraza C*.  Emotional Processing in Healthy Ageing, Mild Cognitive Impairment, and Alzheimer’s Disease. International Journal of Environmental Research and Public Health. 2021. 18(5):2770. Doi.org/10.3390/ijerph18052770.

> Mañas-Padilla MC Gil-Rodríguez S Sampedro-Piquero P Ávila-Gámiz F Rodríguez de Fonseca F Santín LJ Castilla-Ortega E. Remote memory of drug experiences coexists with cognitive decline and abnormal adult neurogenesis in an animal model of cocaine-altered cognition. Addiction Biology, 2021. 26(2): e12886. doi: 10.1111/adb.12886.

> Medina-Vera D, Rosell-Valle C, López-Gambero AJ, Navarro JA, Zambrana-Infantes EN, Rivera P, Santín LJ, Suarez J, Rodríguez de Fonseca F. Imbalance of endocannabinoid/lysophosphatidic acid receptors marks the severity of Alzheimer’s disease in a preclinical model: a therapeutic opportunity. Biology. 2020. 9/11: 377. Doi: 10.3390/biology9110377.

> García Marchena N, Pizarro N, Pavón FJ, Martínez M, Flores López M, Requena N, Araos P, Silva Peña D, Suárez J, Santín LJ, de la Torre R, Rodríguez de Fonseca F, Serrano A. Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients. Scientific Reports, 2020. 10: 17163. doi: 10.1038/s41598-020-74155-0.

> Sampedro-Piquero P, Vicario S, Pérez-Rivas S, Venero C, Baliyan S, Santín LJ. Salivary Cortisol Levels Are Associated with Craving and Cognitive Performance in Cocaine-Abstinent Subjects: A Pilot Study. Brain Sciences, 2020. 10 (10), 682. doi: 10.3390/brainsci10100682.

> Sampedro-Piquero P, Millón C, Moreno-Fernández RD, García-Fernández M, Diaz-Cabiale Z, Santin LJ. Treadmill Exercise Buffers Behavioral Alterations Related to Ethanol Binge-Drinking in Adolescent Mice. Brain Sciences, 2020. 10 (9), 576. doi: 10.3390/brainsci10090576.

> García-Marchena N, Maza-Quiroga R, Serrano A, Barrios V, Requena-Ocaña N, Suárez J, Chowen JA, Argente J, Rubio G, Torrens M, López-Gallardo M, Marco EM, Castilla-Ortega E, Santín LJ, Rodríguez de Fonseca F, Pavón FJ, Araos P. Abstinent patients with alcohol use disorders show an altered plasma cytokine profile: Identification of both interleukin 6 and interleukin 17A as potential biomarkers of consumption and comorbid liver and pancreatic diseases. Journal of Psychopharmacology, 2020. 34(11):1250-1260. doi: 10.1177/0269881120928176.

> Vicario S, Pérez-Rivas A, Ladrón de Guevara-Miranda D, Santín LJ, Sampedro-Piquero P. Cognitive reserve mediates the severity of certain neuropsychological deficits related to cocaine use disorder. Addictive Behaviors. 2020. 107, 106399. doi: 10.1016/j.addbeh.2020.106399.

> Castilla-Ortega E, Santín LJ. Adult hippocampal neurogenesis as a target for cocaine addiction: a review of recent developments. Current Opinion in Pharmacology. 2020. 50: 109-116. doi: 10.1016/j.coph.2019.10.002.

> Lucas I, Urieta P, Balada F, Blanco E, Aluja A. Differences in prefrontal cortex activity based on difficulty in a working memory task using near-infrared spectroscopy. Behavioural Brain Research, 2020. 392:112722. doi:  10.1016/j.bbr.2020.112722

> Aluja A, Balada F, Blanco E, Lucas I, Blanch A.  Startle reflex modulation by affective face "Emoji" pictographs.  Psychological Research, 2020. 84(1): 15-22. doi:  10.1007/s00426-018-0991-x 

> Montesinos J Castilla-Ortega E Sánchez-Marín L Montagud-Romero S Araos P Pedraz M Porras-Perales O García-Marchena N Serrano A Suárez J Baixeras E Rodríguez-Arias M Santín LJ Miñarro J Guerri C Rodríguez de Fonseca F Pavón FJ. Cocaine-induced changes in CX3CL1 and inflammatory signaling pathways in the hippocampus: Association with IL1β. Neuropharmacology, 2020. 162:107840. doi: 10.1016/j.neuropharm.2019.107840.

> Moreno-Fernández RD Rosell-Valle C Bacq A Zanoletti O Cifuentes M Pérez-Martín M Gavito AL García-Fernández MI Estivill-Torrús G Rodríguez de Fonseca F Santín LJ Sandi C Pedraza C. LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance. Neuropharmacology, 2020. 164: 107896. doi: 10.1016/j.neuropharm.2019.107896.

> Gónzalez de San Román E Manuel I Ledent C Chun J Rodríguez de Fonseca F Estivill-Torrús G Santín LJ Rodríguez-Puertas R. CB1 and LPA1 Receptors Relationship in the Mouse Central Nervous System. Frontiers in Molecular Neuroscience. 2019. 12:223. doi: 10.3389/fnmol.2019.00223.

> Sampedro-Piquero P Ávila-Gámiz F Moreno Fernández RD Castilla-Ortega E Santín LJ. The presence of a social stimulus reduces cocaine-seeking in a place preference conditioning paradigm. Journal of Psychopharmacology, 2019. 33(12):1501-1511. doi: 10.1177/0269881119874414.

> Culuti D, Ladrón de Guevara-Miranda D, Castilla-Ortega E. Santin LJ, Sampedro-Piquero P. Highlighting the role of cognitive and brain reserve in the substance use disorder field. Current Neuropharmacology, 2019. 17(11):1056-1070. doi: 10.2174/1570159X17666190617100707.

> Sampedro-Piquero P Ladrón de Guevara-Miranda D, Pavon FJ, Serrano A, Suarez J, Rodriguez de Fonseca F, Santin LJ, Castilla-Ortega E. Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation. Neuroscience & Biobehavioral Reviews, 2019. 106:23-48. doi: 10.1016/j.neubiorev.2018.11.015.

> Silva‐Peña D, García‐Marchena N, Alén F, Araos P, Rivera P, Vargas A, García‐Fernández MI, Martín‐Velasco AI, Villanúa MA, Castilla‐Ortega E, Santín L, Pavón FJ, Serrano A, Rubio G, Rodríguez de Fonseca F, Suárez J. Alcohol‐induced cognitive deficits are associated with decreased circulating levels of the neurotrophin BDNF in humans and rats. Addiction Biology, 2019. 24(5): 1019-1033. doi: 10.1111/adb.12668.

> Araos P Vidal R O'Shea E Pedraz M García-Marchena N Serrano A Suárez J Castilla-Ortega E Ruiz JJ Campos-Cloute R Santín LJ Rodríguez de Fonseca F Pavón F Colado M. Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients. Scientific Reports, 2019. 9(1):16842. doi: 10.1038/s41598-019-53312-0.

> Flores-Burgess A, Millón C, Gago B, García-Durán L, Cantero-García N; Coveñas R, Narváez JA, Fuxe K, Santín L, Díaz-Cabiale Z. Galanin (1-15)-fluoxetine interaction in the novel object recognition test. Involvement of 5-HT1A receptors in the prefrontal cortex of the rats. Neuropharmacology. 2019. 155:104-112. doi: 10.1016/j.neuropharm.2019.05.023.

> Millón C, Flores‐Burgess A, Castilla‐Ortega E, Gago B, García‐Fernandez M, Serrano A, Rodriguez de Fonseca F, Narváez JA, Fuxe K, Santín L, Díaz‐Cabiale Z. Central administration of galanin N‐terminal fragment 1–15 decreases the voluntary alcohol intake in rats. Addiction Biology, 2019. 24(1):76-87. doi: 10.1111/adb.12582.

> Ladrón Guevara-Miranda D, Moreno-Fernández RD, Gil-Rodríguez S, Rosell-Valle C, Estivill-Torrús G, Serrano A, Pavón FJ, Rodríguez de Fonseca F, Santín LJ, Castilla-Ortega E. Lysophosphatidic acid-induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine-contextual memory. Addiction Biology, 2019. 24(3):458-470. doi: 10.1111/adb.12612.

> Tabbai s, Moreno-Fernández RD, Zambrana-Infantes E, Nieto-Quero A, Chun A, Garcia-Fernandez M, Estivill-Torrús G, Rodriguez de Fonseca F, Santín LJ Gil Oliveira T, Perez-Martin P, Pedraza C. Effects of the LPA1 receptor deficiency and stress on the hippocampal LPA species in mice. Frontiers in Molecular Neuroscience. 2019. 12:146. doi: https://doi.org/10.3389/fnmol.2019.00146.

> Sampedro-Piquero P, Mañas-Padilla MC, Ávila-Gámiz F, Gil-Rodríguez S, Santín LJ, Castilla-Ortega E. Where to place the rewards? Exploration bias in mice influences performance in the classic hole-board spatial memory test. Animal Cognition. 2019. 22(3):433-443. doi: 10.1007/s10071-019-01256-3.

> Millón C, Flores-Burgess A, Gago B, Alen F, Orio L, García-Durán L, Narváez JA, Fuxe K, Santín L, Díaz-Cabiale Z. Role of the galanin N-terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system. Journal of Psychopharmacology, 2019. 33(6):737-747. doi: 10.1177/0269881119844188.

> Masmudi-Martín M, Navarro-Lobato I, López-Aranda MF, Delgado G, Martín-Montañez E, Quiros-Ortega ME, Carretero-Rey M, Narváez L, Garcia-Garrido MF, Posadas S, López-Téllez F, Blanco E, Jiménez-Recuerda I, Granados-Durán P, Paez-Rueda J, López JC, Khan ZU. RGS14414 treatment induces memory enhancement and rescues episodic memory deficits. FASEB Journal, 2019. 33(11):11804-11820. doi: 10.1096/fj.201900429RR

> Lucas I, Balada F, Blanco E, Aluja A. Prefrontal cortex activity triggered by affective faces exposure and its relationship with neuroticism. Neuropsychologia, 2019. 132: 107146. doi: 10.1016/j.neuropsychologia.2019.107146 

> Rivera P, Silva-Peña D, Blanco E, Vargas A, Arrabal S, Serrano A, Pavón FJ, Bindila L, Lutz B, Rodríguez de Fonseca F, Suárez J. Oleoylethanolamide restores alcohol-induced inhibition of neuronal proliferation and microglial activity in striatum. Neuropharmacology, 2019. 146, 184-197. doi:  10.1016/j.neuropharm.2018.11.037

> Balada F, Lucas I, Blanch A, Blanco E, Aluja A. Neuroticism is associated with reduced oxygenation levels in the lateral prefrontal cortex following exposure to unpleasant images. Physiology & Behavior, 2019; 199, 66-72. doi: 10.1016/j.physbeh.2018.11.002

> Aluja A, Lucas I, Blanch A, Blanco E. Personality and disinhibitory psychopathology in alcohol consumption: a study from the biological-factorial personality models of Eysenck, Gray and Zuckerman. Personality and Individual Differences, 2019; 142: 159-165. doi:  10.1016/j.paid.2019.01.030 

> Aluja A, Balada F, Blanco E, Fibla J, Blanch A. Twenty candidate genes predicting neuroticism and sensation seeking personality traits: A multivariate analysis association approach.  Personality and Individual Differences, 2019. 140: 90-102. doi:  10.1016/j.paid.2018.03.041 

> Sampedro-Piquero P, Moreno-Fernández RD, Mañas-Padilla MC, Gil-Rodríguez S, Gavito AL, Pavón FJ, Pedraza C, García-Fernández M, Ladrón de Guevara-Miranda D, Santín LJ, Castilla-Ortega E. Training memory without aversion: appetitive hole-board spatial learning increases adult hippocampal neurogenesis. Neurobiology of Learning and Memory. 2018. 151:35-42. doi: 10.1016/j.nlm.2018.03.023.

> Sánchez-Marín L, Ladrón de Guevara-Miranda D, Alén F, Moreno-Fernández R, García M, Pedraza C, Pavón FJ, Rodríguez de Fonseca F, Santín LJ, Serrano A, Castilla-Ortega E. Systemic blockade of lysophosphatidic acid signaling with ki16425 modulates the effects of ethanol on the brain and behavior. Neuropharmacology. 2018. 133:189-201. doi: 10.1016/j.neuropharm.2018.01.033.

> García Marchena N, Ladrón Guevara-Miranda D, Pedraz M, Fernando Araos P, Rubio G, Ruiz JJ, Pavón FJ, Serrano A, Castilla-Ortega E, Santín LJ, Rodríguez de Fonseca F. Higher Impulsivity as a Distinctive Trait of Severe Cocaine Addiction among Individuals Treated for Cocaine or Alcohol Use Disorders. Frontiers in Psychiatry. 2018. 9:26. doi: 10.3389/fpsyt.2018.00026.

> Zambrana‐Infantes A, Rosell del Valle C, Ladrón de Guevara‐Miranda D, Galeano P, Castilla‐Ortega E, Rodríguez De Fonseca F, Blanco E, Santín LJ. Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice. Pharmacology, Biochemistry & Behavior. 2018. 166:1-12. Doi: 10.1016/j.pbb.2018.01.002.

> Narváez M, Borroto-Escuela D, Santín L, Millón C, Gago B, Flores-Burgess A, Barbancho MA, Perez de la Mora M, Narváez, JA, Díaz-Cabiale Z, Fuxe K. A novel integrative mechanism in anxiolytic behavior induced by Galanin 2/Neuropeptide Y Y1 receptor interactions on the Amygdala in rats. Frontiers in cellular neuroscience, 2018. 12, 119. doi: 10.3389/fncel.2018.00119.

> Moreno-Fernández R, Tabbai S, Castilla-Ortega E, Pérez-Martín M, Estivill-Torrús G, Rodríguez de Fonseca F, Santín LJ, Pedraza C. Stress, depression, resilience and aging: A role for the LPA-LPA₁ pathway. Current Neuropharmacology, 2018. 16(3):271-283. doi: 10.2174/1570159X15666170710200352.

> Moreno-Fernández RD, Nieto-Quero A, Gómez-Salas FJ, Chun J, Estivill-Torrús G, Rodríguez de Fonseca F, Santín LJ, Pérez-Martín M, Pedraza C. Effects of genetic deletion versus pharmacological blockade of the LPA1 receptor on depression-like behaviour and related brain functional activity. Disease Models & Mechanisms. 2018. 10;11(9). Doi: 10.1242/dmm.035519.

> Blanch A, Lucas I, Balada F, Blanco E, Aluja A. Sex differences and personality in the modulation of the acoustic startle reflex. Physiology & Behavior, 2018. 195:20-27. doi:  10.1016/j.physbeh.2018.07.020  

> Holubiec MI, Romero JI, Suárez J, Portavella M, Fernández-Espejo E, Rodríguez de Fonseca F, Blanco E+, Galeano P+ (+Corresponding Authors). Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia. Psychopharmacology, 2018. 235(10)2929-2945. doi: 10.1007/s00213-018-4982-9

> Rivera P, Fernández-Arjona MM, Silva-Peña D, Blanco E, Vargas A, López-Ávalos MD, Mateos Grondona J, Serrano A, Pavón FJ, Rodríguez de Fonseca F, Suárez J. Pharmacological blockade of fatty acid amide hydrolase (FAAH) by URB597 improves memory and induces changes in microglial morphology and phenotype related to innate immune TLR4 system in the hippocampus despite ethanol exposure. Biochemical Pharmacology, 2018. 157: 244–257. doi: 10.1016/j.bcp.2018.08.005

> Portavella M, Rodríguez-Espinosa N, Galeano P, Blanco E, Romero JI, Holubiec MI, Rodríguez de Fonseca F, Fernández-Espejo E. Oleoylethanolamide and palmitoylethanolamide protect cultured cortical neurons against hypoxia. Cannabis and cannabinoid research, 2018. 3(1): 171-178. doi: 10.1089/can.2018.0013

> García-Cárceles J, Vázquez-Villa H, Brea J, Ladron de Guevara-Miranda D, Cincilla G, Sánchez-Martínez M, Sánchez-Merino A, Algar S, Teresa de Los Frailes M, Roberts RS, Ballesteros JA, Rodríguez de Fonseca F, Benhamú B, Loza MI, López-Rodríguez ML. 2-(Fluoromethoxy)-4'-( S-methanesulfonimidoyl)-1,1'-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson's Disease. Journal of Medicinal Chemistry, 2022. 65(18):12256-12272. doi: 10.1021/acs.jmedchem.2c00949