Publicaciones

Arrabal PM, Visser R, Santos-Ruiz L, Becerra J, Cifuentes M. 
Osteogenic molecules for clinical applications: improving the BMP-collagen system.
Biol Res. 46(4):421-9. 2013

Bagó JR., Aguilar E, Alieva M, Soler-Botija C, Fernandez O, Claros S, Andrades JA, Becerra J, Rubio N, Blanco J.
In vivo imaging of cell differentiation in demineralized bone: a platform for Biomaterial development.
Tissue Eng Part A. 19(5-6):593-603. 2013

Cuenca-López MD, Andrades JA, Zamora-Navas P, Gómez S, Guerado E, Rubio N, Blanco J, Becerra J.
Evaluation of Posterolateral Lumbar Fusion in Sheep Using Mineral Scaffolds Seeded with Cultured Bone Marrow Cells.nternational Journal of Molecular Sciences, 15(12): 23359-23376. 2014

Claros S, Rico-Llanos G, Becerra J, Andrades JA.
A Novel Human TGF-b1 Fusion Protein in Combination with rhBMP-2 Increases Chondro-osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells.
International Journal of Molecular Sciences 15(7):11255-74. 2014.

Andrades JA, Becerra J, Muñoz-Chápuli R, Martínez S, Raya A, García-Sancho J, Moraleda JM. 
Stem cells therapy for regenerative medicine: Principles of present and future practice.
J. Biomedical Science and Engineering, 7, 49-57. 2014

Visser R, Arrabal PM, Santos-Ruiz L, Fernandez-Barranco R, Becerra J, Cifuentes M. 
A collagen-targeted RGD biomimetic peptide to promote osteogenesis.
Tissue Eng Part A 20(1-2):34-44. 2014

Duran I, Csukasi F, Taylor SP, Krakow D, Becerra J, Bombarely A, Marí-Beffa M. 
Collagen duplicate genes of bone and cartilage participate during regeneration of zebrafish fin skeleton.
Gene Expr Patterns 19(1-2):60-9. doi: 10.1016/j.gep.2015.07.004. Epub 2015 Aug 72015 Aug 7. 2015

Villatoro AJ, Fernandez V, Claros S, Rico-Llanos GA, Becerra J and Andrades JA. 
Use of Adipose-Derived Mesenchymal Stem Cells in Keratoconjunctivitis Sicca in a Canine Model.
BioMed Research International. Volume 2015: 1-10. ID 527926. 2015

Felipe Orgaz, Alexandra Dzika, Olga Szychta, Daniel Amat, Flora Barbaa, José Becerrad, and Leonor Santos-Ruiz.
Surface nitridation improves bone cell response to melt-derived bioactive borosilicate glass scaffolds.
Acta Biomaterialia Oct 9. 29:424-434. doi: 10.1016/j.actbio.2015.10.006. Epub 2015 Oct 9. 2016

Visser R, Bodnarova K, Arrabal PM, Cifuentes M, Becerra J.
The combined effect of bone morphogenetic proteins-2 and -6 on osteoblastic differentiation and bone formation.
Journal of Biomedical Materials Research, 104(1):178-85. doi: 10.1002/jbm.a.35546. Epub 2015 Aug 27. 2016

Orgaz F, Amat D, Szycht O, Dzika A, Barba F, Becerra J, Santos-Ruiz L. 
Synthesis of novel ICIE16/BSG and ICIE16/BSG-NITRI bioglasses and description of ionic release kinetics upon immersion in SBF fluid: Effect of nitridation.
Brief 6: 153–157. 2016

Ramiro-Gutiérrez ML, Santos-Ruiz L, Borrego-González S, Becerra J, Díaz-Cuenca A.
In vitro stimulation of MC3T3-E1cells and sustained drug delivery by a hierarchical nanostructured SiO2-CaO-P2O5 scaffold.
Microporous and Mesoporous Materials. 229:31-43. 2016

Vida Y, Collado D, Najera F, Claros S, Becerra J, Andrades JA and Perez-Inestrosa E. 
Dendrimer surface orientation of the RGD peptide affects mesenchymal stem cell adhesion.
RSC Adv., 6: 49839-49844. 2016

Rick Visser, Gustavo Adolfo Rico-Llanos, Hertta Pulkkinen, Jose Becerra. 
Peptides for bone tissue engineering.
Journal of Controlled Release (in press)

Antonio J. Villatoro, Silvia Claros, Viviana Fernandez, Fernando Fariñas, Antonio Moreno, José Becerra, José A. Andrades. 
Mesenchymal Stem Cell Therapy in Feline Proliferative Keratitis.
BMC Vet Res (under revission)

Gustavo A. Rico-Llanos, Jose Becerra, Rick Visser.
Insulin-like growth factor-1 enhances the osteogenic activity of bone morphogenetic protein-6 (BMP-6) in vitro and in vivo and its effect is greater than when combined with BMP-2.
Revista: Tissue Engineering and Regenerative Medicine (under revission)

Becerra J, Andrades J A, Santos-Ruiz L, Cifuentes M, Arrabal P M, Visser R, Claros S, Díaz-Cuenca M A, Zamora P y Guerado E. 
Ingeniería tisular y medicina regenerativa esquelética
En: Perspectivas en la investigación con células troncales. Aspectos científicos, éticos y legales. coordinador: M. Moreno Muñoz.
Editorial Comares (Granada), pp: 31-44 (2010). ISBN:978-84-9836-68-8.

Cano J R, Santos Ruiz L, Guerado E, Becerra J.
Osteoprogenitor cell adhesiveness to a titanium mesh. A clinically relevant hypothesis for revision surgery in hip replacement.
Hip Int; 20 (Suppl 7): S102-S105 (2010).

Cuenca-López MD, Peris JL, Garcia-Roselló M, Atienza C, Prat J, Becerra J, Andrades JA.
Action of recombinant human BMP-2 on fracture healing in rabbits is dependent on the mechanical environment.
J. Tissue Engineering and Regenerative Medicine. 4(7):543-52 (2010)

Becerra J, Andrades JA, Guerado E, Zamora P, López-Puertas JM, Reddi AH. 
Articular cartilage: structure and regeneration
Tissue Eng. Part B Rev 16(6): 617-627 (2010)

Guerado E, Cerván A, Ortega JA, Rodríguez Solera M, Andrades JA, Zamora P, Cuenca-López MD, Prats I, Hernández MC, Becerra J.
Diseño de un programa de investigación sobre utilización de terapia celular y BMP en artrodesis lumbar
Rev Esp Cir Ortop Traumatol 54(Supl 1): 11-18 (2010)

Durán I, Marí-Beffa M, Santamaría JA, Becerra J, Santos-Ruiz L. 
Freeze substitution followed by low melting point wax embedding preserves histomorphology and allows protein and mRNA localization techniques
Microsc Res Tech 74(5):440-8 (2011)

Becerra, J, Santos-Ruiz, L, Andrades, JA, Marí-Beffa, M. 
The stem cell niche should be a key issue for cell therapy in regenerative medicine.
Stem Cell Rev and Rep. 7 (2), 248-255 (2011)

Durán I, Marí-Beffa M, Santamaría JA, Becerra J, Santos-Ruiz L. 
Actinotrichia collagens and their role in fin formation.
Dev Biol. 354(1):160-72 (2011)

Reddi AH, Becerra J, Andrades JA. 
Nanomaterials and Hydrogel Scaffolds for Articular Cartilage Regeneration
Tissue Eng. Part B Rev 17(5):301-5. 2011

Andrades JA, Motaung SC, Jimenez-Palomo P, Claros S, Lopez-Puerta JM, Becerra J, Schmid TM, Reddi AH.
Induction of superficial zone protein (SZP)/lubricin/PRG 4 in muscle-derived mesenchymal stem/progenitor cells by transforming growth factor-beta1 and bone morphogenetic protein-7.
Arthritis Res Ther. 14(2):R72 (2012)

Claros S, Rodríguez-Losada N, Cruz E, Guerado E, Becerra J, Andrades JA.
Characterization of adult stem/progenitor cell populations from bone marrow in a three-dimensional collagen gel culture system
Cell Transplantation 2012 Apr 2. [Epub ahead of print].

Andrades JA, Claros S, Jiménez-Palomo P, López-Puerta JM, Zamora-Navas P, Guerado E, Monleón M, Araque MC, Becerra J. 
Skeletal regeneration by mesenchymal stem cells: What else? In: Regenerative Medicine and Tissue Engineering; Cells and Biomaterials, ISBN 979-953-307-002-4. Intech Open Access Publisher, Editor D. Eberli, University of Zurich, CH. Chapter 5, Pp. 70-95.
http://www.intechopen.com/books/regenerative-medicine-and-tissue-engineering-cells-and-biomaterials (2011).

Guerado E, Guerado-Romero G, Andrist T, Amat D, Becerra J, Santos-Ruiz.
Sustitutos Óseos y Terapia Celular. En: Biomateriales y sustitutos óseos en Traumatología y Cirugía Ortopédica. Servicio de Publicaciones de la Universidad de Cádiz. ISBN: 978-84-9828-353-2. pp: 53-65. 2011.

Arrabal PM, Visser R, Santos-Ruiz L, Becerra J, Cifuentes M. 
Strategies for improving the current BMP-based treatments in orthopaedic surgery. Collagen targeted BMPs. In: Bone Morphogenetic Proteins: New Research,, Chapter 8, pp: 151-174. Anja Nohe. Nova Science Publishers Inc. Hauppauge NY (USA). ISBN: 978-1-61942-409-8. https://www.novapublishers.com/catalog/product_info.php?products_id=30774 (2012)

Visser R, Arrabal PM, Santos-Ruiz L, Becerra J, Cifuentes M. 
Basic fibroblast growth factor enhances the osteogenic differentiation induced by bone morphogenetic protein-6 in vitro and in vivo.
Cytokine, 58(1):27-33. 2012

Guerado E, Andrist T, Andrades JA, Santos L 5, Cerván A, Guerado G, Becerra J. 
Artrodesis del raquis. Ciencia Básica
Rev Esp Cir Ortop Traumatol. 56(3):227-244. 2012

Amat D, Becerra J, Medina MA, Quesada AR and Marí-Beffa, M.
Stem cell therapies. Chapter 8, pp: 173-188. EMBRYOLOGY. Updates and highlights on classic topics. edited by L.A. Violin Pereira. Intech Open Science. ISBN 978-953-51-0465-0. 2012

Bagó JR., Aguilar E, Alieva M, Soler-Botija C, Fernandez O, Claros S, Andrades JA, Becerra J, Rubio N, Blanco J. 
In vivo imaging of cell differentiation in demineralized bone: a platform for Biomaterial development
Tissue Eng. Part A. 2012 Sep 26. [Epub ahead of print]

José Becerra y Leonor Santos-Ruiz, Editors. 
Hot Topics in Cell Biology. 278 pages. Chartridge Books Oxford, Oxford, UK. ISBN paperback: 978-1-909287-00-6; ISBN digital (pdf): 978-1-909287-01-3; ISBN digital ebook (epub): 978-1-909287-02-0; ISBN digital ebook (mobi): 978-1-909287-03-7. 2012

Visser R and Becerra J. 
An overview of cell biology in the 21st century. pp: 1-6. In: Hot Topics in Cell Biology. José Becerra y Leonor Santos-Ruiz, Editors 278 pages. Chartridge Books Oxford, Oxford, UK. ISBN paperback: 978-1-909287-00-6; ISBN digital (pdf): 978-1-909287-01-3; ISBN digital ebook (epub): 978-1-909287-02-0; ISBN digital ebook (mobi): 978-1-909287-03-7. 2012

Becerra J. 
The Stem Cell And Its Neighborhood: The Niche Of Stem Cells In Animal And Plant Organisms. pp: 146-150. In: Hot Topics in Cell Biology. José Becerra y Leonor Santos-Ruiz, Editors 278 pages. Chartridge Books Oxford, Oxford, UK
ISBN paperback: 978-1-909287-00-6; ISBN digital (pdf): 978-1-909287-01-3; ISBN digital ebook (epub): 978-1-909287-02-0; ISBN digital ebook (mobi): 978-1-909287-03-7. 2012

M. Vilalta, I.R. Dégano, Y. Chernajovsky, D. Gould, D. Noël, C. Jorgensen, J.A. Andrades, J. Becerra, N. Rubio, J. Blanco
Dual luciferase labelling for non-invasive bioluminescence imaging of mesenchymal stromal cell chondrogenic differentiation in demineralized bone matrix scaffolds
Biomaterials 30:4986–95 (2009)

Visser R, Arrabal P M, Becerra J, Rinas U, Cifuentes M. 
The effect of a rhBMP-2 absorbable collagen sponge-targeted system on bone formation in vivo
Biomaterials 30 (11):2032-37 (2009).

Santos-Ruiz L, Arrabal PM, Visser R, Cifuentes M, Andrades JA, Claros S. Cuenca MD, Díaz-Cuenca A, Becerra J. 
Combining Engineered Growth Factors, Adult Stem Cells and Bioabsorbable Materials for Skeletal Repair and Regeneration
Tissue Eng. Part A, 14 , 826-826 (2008)

Díaz-Cuenca A, Santos-Ruiz L; Becerra J. 
Silica Based Nanomaterials: Characterisation and In Vitro Studies Using Osteoprogenitor Cells
Tissue Eng. Part A, 14, 908-909 (2008).

Claros S, Alonso M, Becerra J, Andrades JA. 
Selection and induction of rat skeletal muscle-derived cells to the chondro-osteogenic lineage
Cellular and Molecular Biology 54(1):1-10 (2008)

Cuenca-López MD, Zamora-Navas P, González JM, Godino M, López-Puertas JM, Guerado E, Becerra J, Andrades JA. 
Adult stem cells applied to tissue engineering and regenerative Medicine
Cellular and Molecular Biology 54(1):40-51 (2008)

Andrades J A, Alonso M, Claros S, Becerra J. 
The effect of type I collagen on osteochondrogenic differentiation in adipose-derived stromal cells in vivo
Cytotherapy.10(6):597-610 (2008)

Santos-Ruiz L, Mowatt DJ, Petiot, A., Tukiainen D, Kellomäki M, Törmälä P, Suokas E, Arstila H, N Ashammakhi, Ferretti P. 
Potential use of craniosynostotic osteoprogenitors cultured in vitro in bioactive scaffolds for bone engineering
Journal of Tissue Engineering and Regenerative Medicine 1(3):199-210 (2007)

Ruiz A, Ujaldón M, Andrades JA, Becerra J, Huang K, Pan T, Saltz J. 
The GPU on biomedical image processing for color and phenotype analysis
Journal Medical Image Analysis BioInformatics

Becerra J, Guerado E, Claros, S, Alonso M, Bertrand ML González C, Andrades JA. 
Autologous human-derived bone marrow cells exposed to a novel TGF-ß1 fusion protein for treatment of critically sized tibial defect
Regenerative Medicine. 1(2): 267-278 (2006)

Becerra J.
Terapia Celular e Ingeniería Tisular para la regeneración esqueléticaPPP
Acta Científica y Tecnológica 10:34-38 (2006)

A. Díaz , T. López, J. Manjarrez, E. Basaldella, J.M. Martínez-Blanes and J.A. Odriozola
Growth of Hydroxyapatite in a Biocompatible Mesoporous Ordered Silica 
Acta Biomaterialia 2: 173-179 (2006)

Becerra J., Andrades J.A., Cifuentes M. y Guerado E. 
Células madre, biotecnología y medicina regenerativa del aparato locomotor
Capítulo 1. En: Actualizaciones en Cirugía Ortopédica y Traumatología (SECOT) VI. Editorial Masson S.A. pp: 3-13 (2006)

Santos-Ruiz L, Santamaría JAS, Becerra J. 
Cytoskeletal dynamics of the teleostean fin ray during fin epimorphic regeneration
Differentiation 73:175-187 (2005)

A. Díaz , S. Hampshire J.F. Yang, T. Ohji, and S. Kanzaki
Comparison of Mechanical Properties of Silicon Nitrides with Controlled Porosities Produced by Different Fabrication Routes
Journal of the American Ceramic Society 88(3)/698-706 (2005)

Guerado E, Godino M, Andrades JA, Becerra J. 
Osteogénesis terapéutica en cirugía del raquis. Bases científicas de la artrodesis vertebral. II
Fundamentos biológicos.Rev Ortop Traum, 49:46-58. (2005)

A. Díaz and S. Hampshire
Controlled Porosity in Silicon Nitride Ceramics and its effects on Properties
Silicates Industriels 69(7-8):205-209 (2004)

A. Díaz and S. Hampshire
Characterisation of Porous Silicon Nitride Materials Produced with Starch
Journal of the European Ceramic Society 24:413-419 (2004)

Akimenko MA, Marí-Beffa M, Becerra J, Géraudie J. 
Old questions, new tools and some answers to the mystery of fin regeneration
Dev Dyn. 226(2): 190-201 (2003)

Andrades JA, Han B, Nimni ME, Ertl DC, Simpkins RT, Arrabal PM, Becerra J. 
A modified rhTGF-beta1 and rhBMP-2 and are effective in initiating a chondro-osseous differentiation pathway in the bone marrow cells cultured in vitro
Connect Tissue Res. 44: 188-197 (2003)

Zauner, H., Begemann, G., Marí-Beffa, M. y Meyer, A. 
Differential regulation of msx genes in the development of the gonopodium, an intromittent organ, ando f the “sword”, a sexually selected trait of swordtail fishes (Xiphophorus)
Evo. Dev. 5,5.: 466-477 (2003)

Marí-Beffa, M; Santamaría, JA; Ruiz-Sanchez, J; Santos-Ruiz, L; Becerra, J. 
Extracellular matrix in fin regeneration in teleosts
Braz J Morphol Sci, 20(2):61-65 (2003)

Guerado E, Díaz A, Arrabal MP, Cifuentes M, Andrades JA, Becerra J. 
Células madre e ingeniería tisular ósea: bases celulares y perspectivas terapéuticas 
Rev Orthop Traumatol, 47: 362-374 (2003)

Andrades JA, Becerra J. 
Bone morphogenetic proteins, collagen matrices and mesenchymal stem cells
Advances In Skeletal Reconstruction Using Bone Morphogenetic Proteins, Vol. 2pp: 54-62. World Scientific Publishing Co. Pte. Ltd. (2002)

Andrades JA, Becerra J. 
Type I collagen and a recombinant TGF-ß1 serve as a scaffold mesenchymal stem cells
Advances In Tissue Banking, Vol. 6, pp: 283-311. World Scientific Publishing Co. Pte. Ltd. (2002)

Zhang F, Clarke JD, Santos-Ruiz L; Ferretti P. 
Differential regulation of fibroblast growth factor receptors in the regenerating amphibian spinal cord in vivo
Neuroscience, 114 (4):837-848 (2002)

Guerado E, Becerra J. 
Los fundamentos de la osteogénesis y la biología reparativa 
Rev Mex Orth Traum, 16 (3): 181- 182 (2002)

Santos-Ruíz L, Ruíz-Sánchez J, Santamaría JA, Becerra J. 
Cell proliferation during blastema formation in teleost fin regeneration
Dev Dynam. 223: 262-272 (2002)

Murciano C, Fernádez TD, Durán I, Maseda D, Ruiz-Sánchez J, Becerra J, Akimenko MA, Marí-Beffa M. 
Ray-Interray Interactions during Fin regeneration of Danio rerio
Developmental Biology. 252: 214-224 (2002)

Becerra J, Cifuentes M, Arrabal MP, Santamaría JA, Andrades JA. 
Engineering recombinant growth factors: a tool for in vitro mesenchymal cells commitment
Int J Dev Biol, 45: 107-108. 2001

Murciano C, Ruiz J, Maseda D, Fernández TD, Duran I, Marín-Giron F, Becerra J, Mari-Beffa, M. 
Ray and inter-ray blastemas interact to control bifurcations of Danio rerio fin rays
Int. J. Dev. Biol. 45: 29-30 (2001)

Santos-Ruiz L, Santamaría JA, Becerra J. 
Differential expression of FGF receptors during zebrafish fin regeneration
Int. J. Dev. Biol. 45: 31-32 (2001)

Becerra J, Andrades JA, Santamaría JA, Cifuentes M, Guerado E. 
Regeneración ósea, terapia celular e ingeniería tisular
Med Clin, Barc. 116: 23-34 (2001)

Andrades JA, Wu LT, Hall FL, Nimni ME, Becerra J. 
Engineering, expression, and renaturation of a collagen-targeted human bFGF fusion protein
Growth Factors. 18: 261-275 (2001)

Andrades JA, Santamaría JA, Wu LT, Hall FL, Nimni ME, Becerra J. 
Production of a recombinant human bFGF with a collagen-binding domain
Protoplasma, 218: 95-103 (2001)

Andrades JA, Santamaría JA, Nimni ME, Becerra J. 
Selection, amplification and induction of a bone marrow cell population to the chondro-osteogenic lineage by rhOP-1: an in vitro and in vivo study
Int J Dev Biol. 45: 689-693 (2001)

Bechara IJ, Joazeiro PP, Marí-Beffa M, Becerra J, Montes GS.
Collagen-afecting drugs impair regeneration of teleost tail fins
J Submicr Cytol Path, 32: 273-280 (2000)

Guerado E, Becerra J, Garcés-Martín GL. 
Planificación prospectiva de la investigación y su aplicación a la producción de un departamento clínico hospitalario 
Todo Hospital, 164: 115-119, 2000

Andrades JA, Han B, Becerra J, Sorgente N, Hall FL, Nimni ME. 
A recombinant human TGF-ß1 fusion protein with collagen-binding domain, promotes migration, growth and differentiation of bone marrow mesenchymal cells
Exp Cell Res, 250: 485-498 (1999)

Marí-Beffa M, Palmqvist P, Marín-Girón F, Montes GS, Becerra J. 
Morphometric study of the regeneration of individual rays in teleost tail finsJ 
Anat. 195:393-405 (1999)

Andrades JA, Santamaría JA, Nimni ME, Becerra J. 
Selección, amplificación, inducción y diferenciación de células osteoprogenitoras: una alternativa para la reparación ósea
Mapfre Medicina, 10: 190-201 (1999)

Gade P, Andrades JA, Nimni ME, Becerra J, Longoria J, Asemanfar N, Sorgente N. 
Nitric oxide mediates hyperglycemia-induced defective migration in cultured endothelial cells
J Vasc Surg, 26: 319-326 (1997)

Gordon EM, Skotzko M, Kundu RK, Han B, Andrades J, Nimni ME, Anderson WF, Hall FL. 
Capture and expansion of bone marrow-derived mesenchymal progenitor cells with a transforming growth factor-ß1-von Willebrand’s factor fusion protein for retrovirus-mediated delilvery of coagulation factor IX
Hum Gene Ther, 8: 1385-1394 (1997)

Becerra J, Andrades JA, Ertl DC, Sorgente N, Nimni ME. 
Demineralized bone matrix mediates differentiation of bone marrow stromal cells in vitro: effect of age of cell donor
J Bone Miner Res, 11: 1703-1714 (1996)

Andrades JA, Nimni ME, Becerra J, Eisenstein R, Davis M, Sorgente N. 
Complements proteins are present in developing endochondral bone and may mediate cartilage cell death and vascularization
Exp Cell Res, 227: 208-213. 1996

Santamaría JA, Marí-Beffa M, Santos-Ruiz L, Becerra J. 
Incorporation of Bromodeoxyuridine in regenerating fin tissue of the goldfish Carassius auratus
J Exp Zool, 275 (4): 300-307 (1996)